Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity

Serine clamp of Clostridium perfringens binary toxin BECb (CPILEb)-pore confers cytotoxicity and enterotoxicity

Abstract BEC (CPILE) is a virulence factor of the pathogen, Clostridium perfringens, which has caused foodborne outbreaks in Japan. BEC is a binary toxin that comprises the enzymatic A-component (BECa) and the B-component (BECb); the latter forms a membrane pore to translocate the A-component into t...

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Main Authors: Toru Yoshida, Chie Monma, Yuki Ninomiya, Sotaro Takiguchi, Shoko Fujita, Yuto Uchida, Noriaki Sakoda, Vladimir A. Karginov, Jun-ichi Kishikawa, Tomohito Yamada, Ryuji Kawano, Hideaki Tsuge
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08519-5
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https://doi.org/10.1038/s42003-025-08519-5

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