Codon usage modulates the relationship between the burden and yield of protein overexpression
Abstract Background Excess utilization of translational resources is a critical source of burden on cells engineered to overexpress exogenous proteins. To improve translational efficiency, researchers often modify codon usage in an exogenous gene to more closely match the composition of a host organ...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
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| Series: | Journal of Biological Engineering |
| Online Access: | https://doi.org/10.1186/s13036-025-00521-z |
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