Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

Abstract Anti-NMDA receptor (NMDAR) encephalitis is a devastating disease with severe psychiatric and neurological symptoms believed to be caused by pathogenic autoantibodies that bind to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) crosslinking adjacent NMDARs and driving thei...

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Main Authors: Atsuo Kanno, Takuya Kito, Masashi Maeda, Shanni Yamaki, Yasushi Amano, Takuya Shimomura, Margarita Anisimova, Naomi Kanazawa, Koichiro Suzuki, Amir Razai, Takuma Mihara, Kaori Kubo, Takeshi Shimada, Koji Nakamura, Naoko Nomura, Yuji Kondo, Akira Okimoto, Azusa Sugiyama, Deborah Park, Ivar Stein, Samuel Petshow, Valentin Vandendoren, Sanela Bilic, Roghiye Kazimi, Vallari Eastman, Scott J. Snipas, Mathew Mitchell, Mari Maurer, Marty Jefson, Jay Lichter, Daisuke Yamajuku, Hiroki Shirai, Megumi Adachi, Daniel J. Hoeppner, Satoshi Kubo, Karen Zito, Takahiro Iizuka, Peter Flynn, Mitsuyuki Matsumoto
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60628-1
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https://doi.org/10.1038/s41467-025-60628-1

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