Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy

Abstract Brain metastases are a frequent and debilitating manifestation of advanced cancer. Here, we collect and analyze neuroimaging of 3,065 cancer patients with 13,067 brain metastases, representing an extensive collection for research. We find that metastases predominantly localize to high perfu...

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Main Authors: Jorge Barrios, Evan Porter, Dante P. I. Capaldi, Taman Upadhaya, William C. Chen, Julian R. Perks, Aditya Apte, Michalis Aristophanous, Eve LoCastro, Dylan Hsu, Payton H. Stone, Javier E. Villanueva-Meyer, Gilmer Valdes, Fei Jiang, Michael Maddalena, Ase Ballangrud, Kayla Prezelski, Hui Lin, Jinger Y. Sun, Muhtada A. K. Aldin, Oi Wai Chau, Benjamin Ziemer, Maasa Seaberg, Penny K. Sneed, Jean L. Nakamura, Lauren C. Boreta, Shannon E. Fogh, David R. Raleigh, Jessica Chew, Harish Vasudevan, Soonmee Cha, Christopher Hess, Ruben Fragoso, David B. Shultz, Luke Pike, Shawn L. Hervey-Jumper, Derek S. Tsang, Philip Theodosopoulos, Daniel Cooke, Stanley H. Benedict, Ke Sheng, Jan Seuntjens, Catherine Coolens, Joseph O. Deasy, Steve Braunstein, Olivier Morin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59584-7
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