Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets

Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets

Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella (MMAF). Distinct projections encircling the central microtubules of the spermatozoal axoneme play pivotal roles in flagellar bending and spermatozoal movement. Mammalian sperm-asso...

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Bibliographic Details
Main Authors: Tao Liu, Fazal Rahim, Meng-Lei Yang, Meftah Uddin, Jing-Wei Ye, Imtiaz Ali, Yousaf Raza, Abu Mansoor, Muhammad Shoaib, Mujahid Hussain, Ihsan Khan, Basit Shah, Asad Khan, Ahmad Nisar, Hui Ma, Bo Xu, Wasim Shah, Qing-Hua Shi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-03-01
Series:Asian Journal of Andrology
Subjects:
c1a projection
central apparatus
male infertility
multiple morphological abnormalities of the flagella
spag17
Online Access:https://journals.lww.com/10.4103/aja202496
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