A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.

A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.

Risk factors for atherosclerosis accelerate the senescence of vascular endothelial cells and promote atherogenesis by inducing vascular inflammation. A hallmark of endothelial senescence is the persistent up-regulation of pro-inflammatory genes. We identified CDC42 signaling as a mediator of chronic...

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Main Authors: Takashi K Ito, Masataka Yokoyama, Yohko Yoshida, Aika Nojima, Hidetoshi Kassai, Kengo Oishi, Sho Okada, Daisuke Kinoshita, Yoshio Kobayashi, Marcus Fruttiger, Atsu Aiba, Tohru Minamino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0102186
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https://doi.org/10.1371/journal.pone.0102186

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