Blockade of the STAT3/BCL-xL Axis Leads to the Cytotoxic and Cisplatin-Sensitizing Effects of Fucoxanthin, a Marine-Derived Carotenoid, on Human Bladder Urothelial Carcinoma Cells

Blockade of the STAT3/BCL-xL Axis Leads to the Cytotoxic and Cisplatin-Sensitizing Effects of Fucoxanthin, a Marine-Derived Carotenoid, on Human Bladder Urothelial Carcinoma Cells

Bladder cancer is a globally prevalent urological malignancy, with transitional carcinoma (TCC) representing the majority of cases. Cisplatin is the primary drug for metastatic bladder cancer chemotherapy; however, its application is limited by nephrotoxicity and resistance. Signal Transducer and Ac...

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Bibliographic Details
Main Authors: Wen-Chyi Dai, Tzu-Hsuan Chen, Tzu-Ching Peng, Yung-Ching He, Chao-Yu Hsu, Chia-Che Chang
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Marine Drugs
Subjects:
fucoxanthin
cisplatin
bladder cancer
STAT3
BCL-xL
apoptosis
Online Access:https://www.mdpi.com/1660-3397/23/2/54
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