Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology

Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology

Abstract PIEZO1 is critical to numerous physiological processes, transducing diverse mechanical stimuli into electrical and chemical signals. Recent studies underscore the importance of visualizing endogenous PIEZO1 activity and localization to understand its functional roles. To enable physiologica...

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Main Authors: Gabriella A. Bertaccini, Ignasi Casanellas, Elizabeth L. Evans, Jamison L. Nourse, George D. Dickinson, Gaoxiang Liu, Sayan Seal, Alan T. Ly, Jesse R. Holt, Tharaka D. Wijerathne, Shijun Yan, Elliot E. Hui, Jerome J. Lacroix, Mitradas M. Panicker, Srigokul Upadhyayula, Ian Parker, Medha M. Pathak
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59150-1
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https://doi.org/10.1038/s41467-025-59150-1

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