An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream

An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream

Lecithinized superoxide dismutase (PC-SOD) was found to have a significantly improved half-life in the bloodstream and better pharmacological effects compared with unmodified SOD. However, there is no direct evidence that parenterally administered PC-SOD decreases superoxide levels in blood and tiss...

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Main Authors: Dessislava Lazarova, Plamen Getsov, Rumiana Bakalova, Biliana Nikolova, Severina Semkova, Zhivko Zhelev, Zhiwei Qiao, Tomohiro Ishikawa, Koichiro Fukuda, Kensuke Osada, Milka Mileva, Tohru Mizushima, Ichio Aoki
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
redox state
inflammation
oxidative stress
lecithinized superoxide dismutase
EPR spectroscopy
Online Access:https://www.mdpi.com/1420-3049/30/9/1882
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