Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status
Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the “diseasome of physical i...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/584205 |
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| author | Nelo Eidy Zanchi Felipe Natali Almeida Fábio Santos Lira José César Rosa Neto Humberto Nicastro Claudia Ribeiro da Luz Mário Alves de Siqueira Filho Vitor Felitti Mariz Vainzof Marilia Seelaender Jacques R. Poortmans Antonio Herbert Lancha |
| author_facet | Nelo Eidy Zanchi Felipe Natali Almeida Fábio Santos Lira José César Rosa Neto Humberto Nicastro Claudia Ribeiro da Luz Mário Alves de Siqueira Filho Vitor Felitti Mariz Vainzof Marilia Seelaender Jacques R. Poortmans Antonio Herbert Lancha |
| author_sort | Nelo Eidy Zanchi |
| collection | DOAJ |
| description | Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the “diseasome of physical inactivity”. In contrast, the protective effect of regular exercise against diseases associated with chronic inflammation may to some extent be ascribed to an anti-inflammatory effect. The so called “acute exercise threshold”, the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. The major concern is related to the level of the threshold: “exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences”. Nonetheless, if the mechanical stimulus is too weak to disrupt cellular homeostasis, training adaptations will not occur. Answering these questions could present practical applications, especially during inflammatory diseases associated with detrimental muscle effects and could theoretically constitute a “new” therapeutic approach to treat/improve an inflammatory state. This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise. |
| format | Article |
| id | doaj-art-86a27d1a7bac4817a51a19d46c2cf439 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-86a27d1a7bac4817a51a19d46c2cf4392025-02-03T06:04:56ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/584205584205Renewed Avenues through Exercise Muscle Contractility and Inflammatory StatusNelo Eidy Zanchi0Felipe Natali Almeida1Fábio Santos Lira2José César Rosa Neto3Humberto Nicastro4Claudia Ribeiro da Luz5Mário Alves de Siqueira Filho6Vitor Felitti7Mariz Vainzof8Marilia Seelaender9Jacques R. Poortmans10Antonio Herbert Lancha11Laboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, 05508-030 São Paulo, SP, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilDepartment of Physiology, Division of Nutrition Physiology, Federal University of São Paulo, 04020-060 São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, 05508-030 São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, 05508-030 São Paulo, SP, BrazilDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, 05508-030 São Paulo, SP, BrazilHuman Genome Research Center, Institute of Biosciences, University of São Paulo, 05508-090 São Paulo, SP, BrazilCancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, SP, BrazilLaboratory for Applied Sport Nutrition, Faculty of Motility Sciences, Free University of Brussels, CP640 Brussels, BelgiumLaboratory of Applied Nutrition and Metabolism, Physical Education and Sport School, University of São Paulo, 05508-030 São Paulo, SP, BrazilPhysical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the “diseasome of physical inactivity”. In contrast, the protective effect of regular exercise against diseases associated with chronic inflammation may to some extent be ascribed to an anti-inflammatory effect. The so called “acute exercise threshold”, the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. The major concern is related to the level of the threshold: “exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences”. Nonetheless, if the mechanical stimulus is too weak to disrupt cellular homeostasis, training adaptations will not occur. Answering these questions could present practical applications, especially during inflammatory diseases associated with detrimental muscle effects and could theoretically constitute a “new” therapeutic approach to treat/improve an inflammatory state. This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise.http://dx.doi.org/10.1100/2012/584205 |
| spellingShingle | Nelo Eidy Zanchi Felipe Natali Almeida Fábio Santos Lira José César Rosa Neto Humberto Nicastro Claudia Ribeiro da Luz Mário Alves de Siqueira Filho Vitor Felitti Mariz Vainzof Marilia Seelaender Jacques R. Poortmans Antonio Herbert Lancha Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status The Scientific World Journal |
| title | Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status |
| title_full | Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status |
| title_fullStr | Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status |
| title_full_unstemmed | Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status |
| title_short | Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status |
| title_sort | renewed avenues through exercise muscle contractility and inflammatory status |
| url | http://dx.doi.org/10.1100/2012/584205 |
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