Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells

Abstract All extant jawless vertebrates (lampreys and hagfishes) possess a unique adaptive immune system characterized by highly variable lymphocyte receptors (VLR) that are assembled in developing lymphocytes using leucine-rich-repeat donor cassettes. Five VLR types have been identified in lampreys...

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Bibliographic Details
Main Authors: Sabyasachi Das, Francisco Fontenla-Iglesias, Masayuki Hirano, Ryo Morimoto, Byron B. Au-Yeung, Yashuo Wang, Weiming Li, Thomas Boehm, Jonathan P. Rast, Max D. Cooper
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61187-1
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