Identification of dynamic network biomarker ITGB1 for erlotinib pre-resistance using single-cell differential covariance entropy

Identification of dynamic network biomarker ITGB1 for erlotinib pre-resistance using single-cell differential covariance entropy

Acquired erlotinib resistance is the primary cause of treatment failure in patients with non-small cell lung cancer (NSCLC). Most current research focuses on end-stage resistance, whereas early events leading to resistance have been largely overlooked. In this study, we developed a novel dynamic net...

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Main Authors: Xuerong Gu, Qiwen Huang, Yucheng Huang, Dandan Ding, Jiayuan Zhong, Shengming Lin, Yingxin Yu, Hui Wang, Chang Liu, Pei Chen, Chunbo Chen, Wei Luo, Haiyu Zhou, Rui Liu, Fei Ling
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
pre-resistance state
non-small cell lung cancer
dynamic network biomarker
ITGB1
single-cell differential covariance entropy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000621
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