Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats
Inflammatory mediators play a criticial role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/92642 |
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| author | Yan-Hong Zhou Jie-Ping Yu Yi-Fei Liu Xiao-Jun Teng Mei Ming Peng Lv Ping An Shi-Quan Liu Hong-Gang Yu |
| author_facet | Yan-Hong Zhou Jie-Ping Yu Yi-Fei Liu Xiao-Jun Teng Mei Ming Peng Lv Ping An Shi-Quan Liu Hong-Gang Yu |
| author_sort | Yan-Hong Zhou |
| collection | DOAJ |
| description | Inflammatory mediators play a criticial role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic administration with 2,4,6-trinitrobenzene sulfonic acid (TNBS, 150 mg/kg). EGB in doses of (50, 100, 200 mg/kg) was administered for 4 weeks to protect colitis. The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF-α, NF-κBp65, and IL-6 in the colon tissues of experimental colitis in a dose-dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation. |
| format | Article |
| id | doaj-art-868af509027b4bb29d354d31af46e655 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-868af509027b4bb29d354d31af46e6552025-02-03T01:24:21ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/9264292642Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in RatsYan-Hong Zhou0Jie-Ping Yu1Yi-Fei Liu2Xiao-Jun Teng3Mei Ming4Peng Lv5Ping An6Shi-Quan Liu7Hong-Gang Yu8Department of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Biomedical Engineering, Xianning University, Hubei Province, Xianning 437100, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital, Wuhan University, Hubei Province, Wuhan 430060, ChinaInflammatory mediators play a criticial role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic administration with 2,4,6-trinitrobenzene sulfonic acid (TNBS, 150 mg/kg). EGB in doses of (50, 100, 200 mg/kg) was administered for 4 weeks to protect colitis. The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF-α, NF-κBp65, and IL-6 in the colon tissues of experimental colitis in a dose-dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation.http://dx.doi.org/10.1155/MI/2006/92642 |
| spellingShingle | Yan-Hong Zhou Jie-Ping Yu Yi-Fei Liu Xiao-Jun Teng Mei Ming Peng Lv Ping An Shi-Quan Liu Hong-Gang Yu Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats Mediators of Inflammation |
| title | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats |
| title_full | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats |
| title_fullStr | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats |
| title_full_unstemmed | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats |
| title_short | Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats |
| title_sort | effects of ginkgo biloba extract on inflammatory mediators sod mda tnf α nf κbp65 il 6 in tnbs induced colitis in rats |
| url | http://dx.doi.org/10.1155/MI/2006/92642 |
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