Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

Loss of the Aspergillus fumigatus spindle assembly checkpoint components, SldA or SldB, generates triazole heteroresistant conidial populations

ABSTRACT The opportunistic pathogen Aspergillus fumigatus is the chief causative agent of human invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the biosynthesis of ergosterol, a vital component of the fungal cell membra...

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Main Authors: Ashley V. Nywening, Harrison I. Thorn, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Wenbo Ge, John G. Gibbons, Jarrod R. Fortwendel
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Aspergillus fumigatus
triazole resistance
antifungal susceptibility
antifungal tolerance
ergosterol biosynthesis
spindle assembly checkpoint
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00536-25
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https://journals.asm.org/doi/10.1128/spectrum.00536-25

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