HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion

HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion

ObjectivesHPV infection and HPV DNA integration can lead to cervical cancer, but the relationship with lesion severity is unclear. This study aimed to investigate the correlation between HPV integration profile and cervical lesion extent.Materials and methodsTwenty patients representing cervicitis,...

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Main Authors: Ying Hou, Shoufeng Ni, Xin Liu, Xingyu Liu, Nan Wang, Fuqiang Xu, Jianyong Gao, Yanmei Li, Yuxiang Zhou, Huadong Tang, Meina Bian, Xiulan Li, Lili Zhang, Weiwei Wang, Qing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
human papillomavirus
cervical lesions
cervical cancer
nanopore sequencing
virus integration
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1522550/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1522550/full

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