Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy

Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy

Abstract While the etiology of most cases of Parkinson’s disease (PD) are idiopathic, it has been estimated that 5–10% of PD arise from known genetic mutations. The first mutations described that leads to the development of an autosomal dominant form of PD are in the SNCA gene that codes for the pro...

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Bibliographic Details
Main Authors: Matthew D. Byrne, Peyman Petramfar, Jae-Kyung Lee, Richard Jay Smeyne
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
a-Synuclein
Microglia
SNpc
Preformed filaments
Lewy bodies
Neuroinflammation
Online Access:https://doi.org/10.1038/s41598-025-10705-8
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https://doi.org/10.1038/s41598-025-10705-8

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