Early Activation of Lung CD8+ T Cells After Immunization with Live Plasmodium berghei Malaria Sporozoites

Early Activation of Lung CD8+ T Cells After Immunization with Live Plasmodium berghei Malaria Sporozoites

Background: Two novel malaria vaccines, RTS,S and R21, mark a significant step forward in malaria research, but eradication demands vaccines with higher efficacy. Recent trials using late-arresting genetically attenuated parasites (LA-GAP) highlight their effectiveness as next-generation vaccines,...

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Main Authors: Roos van Schuijlenburg, Chanel Naar, Stefanie van der Wees, Severine Chevalley-Maurel, Nikolas Duszenko, Laura de Bes-Roeleveld, Eva Iliopoulou, Emma Houlder, Fiona Geurten, Els Baalbergen, Meta Roestenberg, Blandine Franke-Fayard
Format: Article
Language:English
Published: Case Western Reserve University 2025-03-01
Series:Pathogens and Immunity
Subjects:
CD8+ T-cells
Lung
LA-GAP
Malaria
Priming
Online Access:https://www.paijournal.com/index.php/paijournal/article/view/794
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