KAT6B overexpression in mice causes aggression, anxiety, and epilepsy

KAT6B overexpression in mice causes aggression, anxiety, and epilepsy

Summary: Loss of the gene encoding the histone acetyltransferase KAT6B (MYST4/MORF/QKF) causes developmental brain abnormalities as well as behavioral and cognitive defects in mice. In humans, heterozygous variants in the KAT6B gene cause two cognitive disorders, Say-Barber-Biesecker-Young-Simpson s...

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Main Authors: Maria I. Bergamasco, Ezgi Ozturk, Pablo M. Casillas-Espinosa, Alexandra L. Garnham, Waruni Abeysekera, Verena C. Wimmer, Pradeep Rajasekhar, Hannah K. Vanyai, Lachlan Whitehead, Marnie E. Blewitt, Kelly Rogers, Adam P. Vogel, Anthony J. Hannan, Gordon K. Smyth, Nigel C. Jones, Tim Thomas, Anne K. Voss
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Behavioral neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002135
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http://www.sciencedirect.com/science/article/pii/S2589004225002135

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