A Prospective Pilot Clinical Study reveals a promising non-toxic anti-biofilm activity of gentamicin-EDTA-Na₂ Central Venous Catheter Lock Solution

A Prospective Pilot Clinical Study reveals a promising non-toxic anti-biofilm activity of gentamicin-EDTA-Na₂ Central Venous Catheter Lock Solution

Objectives: The treatment of long-term intravenous catheter-related bloodstream infections (LTIVC-related BSI) often requires catheter removal or conservative treatment using intra-catheter locks, with a 50–60% success rate. We previously demonstrated the synergistic effect of a combination of genta...

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Main Authors: David Lebeaux, Bérénice Souhail, Tan-Phuc Bui-Van, Lénaig Le-Fouler, Matthieu Lafaurie, Raphael Lepeule, Etienne Canoui, Victoire de Lastours, Antoine Froissart, Damien Blez, Christophe Beloin, Jean-Marc Ghigo, Fabrice Pirot, Carole Dhelens, Sandrine Fernandes-Pellerin
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Journal of Infectious Diseases
Subjects:
Biofilm
conservative treatment
Totally implantable venous access port
Antibiotic lock therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971225001572
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