Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Abstract Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that inc...

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Main Authors: Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang
Format: Article
Language:English
Published: Nature Portfolio 2016-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10872
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https://doi.org/10.1038/ncomms10872

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