The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis

Abstract Recent research has shown that cognitive reserve is associated with better cognitive abilities in ALS/MND, and that a slow brain ageing speed is associated with intact cognition in ALS. This study compares the effects of cognitive reserve and the predicted brain age difference (PAD) on the...

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Bibliographic Details
Main Authors: Anna G. M. Temp, Gaël Nils Tarakdjian, Elisabeth Kasper, Judith Machts, Jörn Kaufmann, Stefan Vielhaber, Johannes Prudlo, James H. Cole, Martin Dyrba, Stefan Teipel, Andreas Hermann
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-97509-y
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