The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively. We identified new CDK phosphorylation sites on CtIP and foun...

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Main Authors: Hailong Wang, Linda Z Shi, Catherine C L Wong, Xuemei Han, Patty Yi-Hwa Hwang, Lan N Truong, Qingyuan Zhu, Zhengping Shao, David J Chen, Michael W Berns, John R Yates, Longchuan Chen, Xiaohua Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1003277
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https://doi.org/10.1371/journal.pgen.1003277

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