Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.

Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy...

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Main Authors: Yunpeng Wang, Wesley K Thompson, Andrew J Schork, Dominic Holland, Chi-Hua Chen, Francesco Bettella, Rahul S Desikan, Wen Li, Aree Witoelar, Verena Zuber, Anna Devor, Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, Enhancing Neuro Imaging Genetics through Meta Analysis Consortium, Markus M Nöthen, Marcella Rietschel, Qiang Chen, Thomas Werge, Sven Cichon, Daniel R Weinberger, Srdjan Djurovic, Michael O'Donovan, Peter M Visscher, Ole A Andreassen, Anders M Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1005803
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https://doi.org/10.1371/journal.pgen.1005803

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