Development and evaluation of BDNF-loaded PCL/PVA two-layer nerve guidance conduit with enhanced biomechanical and biological properties for peripheral nerve regeneration

Development and evaluation of BDNF-loaded PCL/PVA two-layer nerve guidance conduit with enhanced biomechanical and biological properties for peripheral nerve regeneration

The repair of damaged peripheral nerves and the following restoration of functionality remain significant therapeutic challenges. Hollow nerve conduits currently available do not align with the ideal human model. Successfully mending nerve gaps requires incorporating biomimetic and functional featur...

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Bibliographic Details
Main Authors: Massoumeh Jabbari Fakhr, Mohsen Eslami Farsani, Leyla Fath-Bayati, Reihaneh Seyedebrahimi, Mehdi Sadrjahani, Fatemeh Kavakebian, Alireza Rezapour
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
BDNF
Two-layer nerve guidance conduit
3D model
Nanofiber
Peripheral nerve regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025011739
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