Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease

Abstract Noradrenaline plays an integral role in learning by optimising behavioural strategies and facilitating choice execution. Testing the noradrenergic framework of learning in the context of human diseases offers a test bed for current normative neuroscience theories and may also indicate thera...

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Bibliographic Details
Main Authors: Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08627-2
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