TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency

TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency

Abstract Progranulin is a pro-protein that is necessary for maintaining lysosomal function. Loss-of-function progranulin (GRN) mutations are a dominant cause of frontotemporal dementia (FTD). Brains of people with FTD due to GRN mutations accumulate lysosomal storage material and exhibit increased e...

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Main Authors: Wren O. Nader, Kaylan S. Brown, Nicholas R. Boyle, Azariah K. Kaplelach, Shaimaa M. Abdelaziz, Skylar E. Davis, Qays Aljabi, Ahmad R. Hakim, Amelia G. Davidson, Giacynta A. Vollmer, Leah C. Wright, J. Bailey Echols, Joelle Saad, Nicholas S. Pena, Andrew E. Arrant
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Progranulin
TFEB
Lysosomes
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-12268-0
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https://doi.org/10.1038/s41598-025-12268-0

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