Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression

Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression

Abstract Background Inclusion Body Myositis is an acquired muscle disease. Its pathogenesis is unclear due to the co-existence of inflammation, muscle degeneration and mitochondrial dysfunction. We aimed to provide a more advanced understanding of the disease by combining multi-omics analysis with p...

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Main Authors: Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Inclusion body myositis
Multi-omics
Transcriptomics
Genomics
Network analysis
Active subnetwork identification
Online Access:https://doi.org/10.1186/s13023-024-03526-x
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https://doi.org/10.1186/s13023-024-03526-x

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