Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness. In the brain, defects in γ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders, whereas...

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Bibliographic Details
Main Authors: Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-02-01
Series:Neural Regeneration Research
Subjects:
diabetic retinopathy
glucagon-like peptide-1
inhibitory synaptic transmission
miniature inhibitory postsynaptic currents
neurodegeneration
neuroprotection
patch-clamp recording
protein kinase c
signaling pathway
visual function
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00001
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https://journals.lww.com/10.4103/NRR.NRR-D-24-00001

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