Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer’s disease

Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer’s disease

Abstract Clinical evidences indicate that multifaceted gait abnormalities may manifest in Alzheimer’s disease (AD) patients, which are associated with cognitive decline. Although the correlation between hippocampal theta power and locomotion has been known for a long time, the mechanisms by how hipp...

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Bibliographic Details
Main Authors: Hong Ni, Zhongzhao Guo, Jie Wang, Zilu Zhu, Chenyi Xia, Ming Xu, Guohui Zhang, Deheng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
5xFAD mouse
Gait
Hippocampus
Theta oscillations
Online Access:https://doi.org/10.1038/s41598-025-95585-8
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https://doi.org/10.1038/s41598-025-95585-8

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