Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy
BACKGROUND: Insulin resistance is more prevalent in the overweight population, which can affect their glucose metabolism. This study explores whether weight status influences the relationship between admission hyperglycemia and outcomes after thrombectomy. METHODS: Four hundred and fifty-two patient...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/bc.bc_28_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556952662933504 |
|---|---|
| author | Tao Tang Xu-Sheng Zhao Zhong-Jun Chen Tie-Ping Fan Aline M. Thomas Man-Hong Zhao Di Li Shen Li |
| author_facet | Tao Tang Xu-Sheng Zhao Zhong-Jun Chen Tie-Ping Fan Aline M. Thomas Man-Hong Zhao Di Li Shen Li |
| author_sort | Tao Tang |
| collection | DOAJ |
| description | BACKGROUND:
Insulin resistance is more prevalent in the overweight population, which can affect their glucose metabolism. This study explores whether weight status influences the relationship between admission hyperglycemia and outcomes after thrombectomy.
METHODS:
Four hundred and fifty-two patients with acute anterior circulation ischemic stroke undergoing thrombectomy were retrospectively analyzed. Hyperglycemia at admission was described as venous blood glucose ≥7.8 mmol/L and overweight as body mass index ≥24 kg/m2. The outcomes included the rates of functional independence (90-day modified Rankin Scale 0–2), symptomatic intracranial hemorrhage within 24 h after thrombectomy, and mortality at 90 days.
RESULTS:
Overall, hyperglycemia at admission decreased the likelihood of functional independence (adjusted odds ratio [OR] 0.50, 95% confidence interval [CI] 0.30–0.83, P = 0.008). Weight status modified the efficacy of admission hyperglycemia on functional independence (P = 0.022 for interaction). Hyperglycemia at admission was negatively associated with functional independence among overweight patients (adjusted OR 0.30, 95% CI 0.15–0.60, P = 0.001) but not among normal-weight patients (adjusted OR 1.13, 95% CI 0.48–2.70, P = 0.776). Weight status did not influence the efficacy of hyperglycemia at admission on mortality (P = 0.201 for interaction) or symptomatic intracerebral hemorrhage (P = 0.105 for interaction).
CONCLUSIONS:
Weight status influenced the effect of hyperglycemia at admission on functional independence after thrombectomy. Hyperglycemia at admission was related to functional independence among overweight patients but not among normal-weight patients. Our findings suggest tight control of glucose may be needed for overweight patients in the thrombectomy setting. |
| format | Article |
| id | doaj-art-8588fa9b7a574d13b3412778fddc5a1b |
| institution | Kabale University |
| issn | 2455-4626 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj-art-8588fa9b7a574d13b3412778fddc5a1b2025-01-07T05:14:06ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262024-12-0110432432910.4103/bc.bc_28_24Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomyTao TangXu-Sheng ZhaoZhong-Jun ChenTie-Ping FanAline M. ThomasMan-Hong ZhaoDi LiShen LiBACKGROUND: Insulin resistance is more prevalent in the overweight population, which can affect their glucose metabolism. This study explores whether weight status influences the relationship between admission hyperglycemia and outcomes after thrombectomy. METHODS: Four hundred and fifty-two patients with acute anterior circulation ischemic stroke undergoing thrombectomy were retrospectively analyzed. Hyperglycemia at admission was described as venous blood glucose ≥7.8 mmol/L and overweight as body mass index ≥24 kg/m2. The outcomes included the rates of functional independence (90-day modified Rankin Scale 0–2), symptomatic intracranial hemorrhage within 24 h after thrombectomy, and mortality at 90 days. RESULTS: Overall, hyperglycemia at admission decreased the likelihood of functional independence (adjusted odds ratio [OR] 0.50, 95% confidence interval [CI] 0.30–0.83, P = 0.008). Weight status modified the efficacy of admission hyperglycemia on functional independence (P = 0.022 for interaction). Hyperglycemia at admission was negatively associated with functional independence among overweight patients (adjusted OR 0.30, 95% CI 0.15–0.60, P = 0.001) but not among normal-weight patients (adjusted OR 1.13, 95% CI 0.48–2.70, P = 0.776). Weight status did not influence the efficacy of hyperglycemia at admission on mortality (P = 0.201 for interaction) or symptomatic intracerebral hemorrhage (P = 0.105 for interaction). CONCLUSIONS: Weight status influenced the effect of hyperglycemia at admission on functional independence after thrombectomy. Hyperglycemia at admission was related to functional independence among overweight patients but not among normal-weight patients. Our findings suggest tight control of glucose may be needed for overweight patients in the thrombectomy setting.https://journals.lww.com/10.4103/bc.bc_28_24endovascular thrombectomyhyperglycemiaoutcomestrokeweight status |
| spellingShingle | Tao Tang Xu-Sheng Zhao Zhong-Jun Chen Tie-Ping Fan Aline M. Thomas Man-Hong Zhao Di Li Shen Li Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy Brain Circulation endovascular thrombectomy hyperglycemia outcome stroke weight status |
| title | Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| title_full | Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| title_fullStr | Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| title_full_unstemmed | Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| title_short | Weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| title_sort | weight status influences the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy |
| topic | endovascular thrombectomy hyperglycemia outcome stroke weight status |
| url | https://journals.lww.com/10.4103/bc.bc_28_24 |
| work_keys_str_mv | AT taotang weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT xushengzhao weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT zhongjunchen weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT tiepingfan weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT alinemthomas weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT manhongzhao weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT dili weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy AT shenli weightstatusinfluencestheeffectofhyperglycemiaatadmissiononclinicaloutcomesafterendovascularthrombectomy |