Optimizing Nodal, Wnt and BMP signaling pathways for robust and efficient differentiation of human induced pluripotent stem cells to intermediate mesoderm cells

Several differentiation protocols have enabled the generation of intermediate mesoderm (IM)-derived cells from human pluripotent stem cells (hPSC). However, the substantial variability between existing protocols for generating IM cells compromises their efficiency, reproducibility, and overall succe...

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Bibliographic Details
Main Authors: Esmeralda Magro-Lopez, Elena Vazquez-Alejo, María de la Sierra Espinar-Buitrago, María Ángeles Muñoz-Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Cell and Developmental Biology
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Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1395723/full
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