OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections.

OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections.

Lantibiotics continue to offer an untapped pipeline for the development of novel antibiotics. We report here the discovery of a novel lantibiotic for the treatment of C. difficile infection (CDI). The leads were selected from a library of over 300 multiple substitution variants of the lantibiotic Mu...

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Bibliographic Details
Main Authors: Johan A Kers, Anthony W DeFusco, Jae H Park, Jin Xu, Mark E Pulse, William J Weiss, Martin Handfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0197467/1/pone.0197467.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T121653Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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