Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model
Multiple organ dysfunction syndrome (MODS) remains a great challenge in critical care because of its common occurrence, high cost of care, and high mortality. Vascular endothelial injury is the initiation step in the development of MODS, and EPCs are essential for the process of organ repair. It is...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/8297391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567040662044672 |
|---|---|
| author | Tianhang Luo Jixin Shu Zhengmao Lu Ting Han Guoen Fang Xuchao Xue |
| author_facet | Tianhang Luo Jixin Shu Zhengmao Lu Ting Han Guoen Fang Xuchao Xue |
| author_sort | Tianhang Luo |
| collection | DOAJ |
| description | Multiple organ dysfunction syndrome (MODS) remains a great challenge in critical care because of its common occurrence, high cost of care, and high mortality. Vascular endothelial injury is the initiation step in the development of MODS, and EPCs are essential for the process of organ repair. It is unclear whether and how caveolin-1 (Cav-1) in EPCs contributes to the pathogenesis of MODS. The present study is aimed at investigating the potential role of Cav-1 in EPCs during MODS. We established a MODS model in pigs, isolated and characterized EPCs from the MODS model, and tracked Cav-1 expression and various in vitro behaviors of EPCs from the MODS model. Then, we knockdown Cav-1 expression with siRNA or induce Cav-1 expression with proinflammatory factors to evaluate potential effects on EPCs. Our results suggest that Cav-1 expression correlated with EPC functions during MODS and Cav-1 regulates the function of endothelial progenitor cells via PI3K/Akt/eNOS signaling during MODS. Thus, Cav-1 in EPCs could be an attractive target for the treatment of MODS. |
| format | Article |
| id | doaj-art-856b64a227ef4ef988d5c2b895dba682 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-856b64a227ef4ef988d5c2b895dba6822025-02-03T01:02:32ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/82973918297391Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS ModelTianhang Luo0Jixin Shu1Zhengmao Lu2Ting Han3Guoen Fang4Xuchao Xue5Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, ChinaDepartment of General Surgery, Gongli Hospital, The Second Military Medical University, Shanghai 200135, ChinaDepartment of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, ChinaDepartment of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, ChinaDepartment of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, ChinaDepartment of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, ChinaMultiple organ dysfunction syndrome (MODS) remains a great challenge in critical care because of its common occurrence, high cost of care, and high mortality. Vascular endothelial injury is the initiation step in the development of MODS, and EPCs are essential for the process of organ repair. It is unclear whether and how caveolin-1 (Cav-1) in EPCs contributes to the pathogenesis of MODS. The present study is aimed at investigating the potential role of Cav-1 in EPCs during MODS. We established a MODS model in pigs, isolated and characterized EPCs from the MODS model, and tracked Cav-1 expression and various in vitro behaviors of EPCs from the MODS model. Then, we knockdown Cav-1 expression with siRNA or induce Cav-1 expression with proinflammatory factors to evaluate potential effects on EPCs. Our results suggest that Cav-1 expression correlated with EPC functions during MODS and Cav-1 regulates the function of endothelial progenitor cells via PI3K/Akt/eNOS signaling during MODS. Thus, Cav-1 in EPCs could be an attractive target for the treatment of MODS.http://dx.doi.org/10.1155/2019/8297391 |
| spellingShingle | Tianhang Luo Jixin Shu Zhengmao Lu Ting Han Guoen Fang Xuchao Xue Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model Mediators of Inflammation |
| title | Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model |
| title_full | Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model |
| title_fullStr | Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model |
| title_full_unstemmed | Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model |
| title_short | Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model |
| title_sort | potential role of caveolin 1 in regulating the function of endothelial progenitor cells from experimental mods model |
| url | http://dx.doi.org/10.1155/2019/8297391 |
| work_keys_str_mv | AT tianhangluo potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel AT jixinshu potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel AT zhengmaolu potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel AT tinghan potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel AT guoenfang potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel AT xuchaoxue potentialroleofcaveolin1inregulatingthefunctionofendothelialprogenitorcellsfromexperimentalmodsmodel |