Study of biological activity of 2-quinoline-2-yl-derivative 1,3-tropolone in experiment

Study of biological activity of 2-quinoline-2-yl-derivative 1,3-tropolone in experiment

Purpose of the study. Was to reveal the antitumor effect of 2‑(6,8‑dimethyl‑5‑nitro‑4‑chloroquinoline‑2‑yl)‑5,6,7‑trichloro‑1,3‑tropolone in subcutaneous PDX models of human lung cancer.Material and methods. The studied tropolone was synthesized using a method of expanding the o‑quinone cycle. Asses...

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Main Authors: E. A. Lukbanova, E. A. Dzhenkova, A. S. Goncharova, A. Yu. Maksimov, E. F. Komarova, V. I. Minkin, Yu. A. Sayapin, E. A. Gusakov, L. Z. Kurbanova, A. A. Kiblitskaya, E. V. Zaikina, M. V. Mindar, M. V. Voloshin, A. V. Shaposhnikov, I. B. Lysenko, N. V. Nikolaeva
Format: Article
Language:Russian
Published: QUASAR, LLC 2022-06-01
Series:Исследования и практика в медицине
Subjects:
tropolones
antitumor activity
balb/c nude mice
xenograft
dose dependent effects
toxic effect
non-small-cell lung carcinoma (nsclc)
Online Access:https://www.rpmj.ru/rpmj/article/view/743
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https://www.rpmj.ru/rpmj/article/view/743

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