Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response

Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response

Protein kinase R (PKR) is a serine/threonine kinase that recognizes double-stranded RNAs (dsRNAs) to initiate innate immune signalling during viral infection. PKR dimerizes on long dsRNAs and undergoes autophosphorylation. Phosphorylated/Activated PKR then catalyses the phosphorylation of numerous s...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiyoon Chung, Yerim Lee, Jimin Yoon, Yoosik Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:RNA Biology
Subjects:
Protein kinase R (PKR)
inflammatory diseases
gene regulation
splicing
cell cycle
differentiation
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2025.2512610
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/15476286.2025.2512610

Similar Items