Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Abstract Kinesin-1 is a processive dimeric ATP-driven motor that transports vital intracellular cargos along microtubules (MTs). If not engaged in active transport, kinesin-1 limits futile ATP hydrolysis by adopting a compact autoinhibited conformation that involves an interaction between its C-term...

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Main Authors: J. Atherton, M. S. Chegkazi, M. Leusciatti, M. Di Palma, E. Peirano, L. S. Pozzer, M. V. A. Meli, S. Pasqualato, T. Foran, G. Morra, R. A. Steiner
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61498-3
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https://doi.org/10.1038/s41467-025-61498-3

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