PARP Inhibition in Colorectal Cancer—A Comparison of Potential Predictive Biomarkers for Therapy

PARP Inhibition in Colorectal Cancer—A Comparison of Potential Predictive Biomarkers for Therapy

<b>Background/Objectives</b>: PARP inhibitors (PARPis) currently play frontline roles in the management of prostate, pancreatic, ovarian and breast cancers, but their roles in colorectal cancer (CRC) management have yet to be clarified. Importantly, the specific predictive biomarkers for...

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Bibliographic Details
Main Author: Abdulaziz Alfahed
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
colorectal cancer
PARP inhibition
predictive biomarkers
large-scale state transition (LST)
microsatellite instability (MSI)
<i>PARP1</i> expression
Online Access:https://www.mdpi.com/1424-8247/18/6/905
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