Targeting the RAGE–RIPK1 binding site attenuates diabetes-associated cognitive deficits

Targeting the RAGE–RIPK1 binding site attenuates diabetes-associated cognitive deficits

Abstract Microglial activation can cause neuroinflammation and the consequent neurological impairments play prominent roles in diabetes-associated cognitive deficits. Receptor-interacting protein kinase 1 (RIPK1) phosphorylation is involved in this deleterious microglial activation, but the exact mo...

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Main Authors: Lin Gao, Shidi Wu, Bin Hu, Qiuyu Zhang, Yifei Wu, Hui Li, Ye Qian, Chengyu Huang, Xiangru Wen, Aifang Cheng, Yuanjian Song, Changjiang Ying, Xiaoyan Zhou
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Receptor-interacting protein kinase 1
The receptor for advanced glycation end products
RIPK1 peptide
Diabetes-associated cognitive deficits
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03489-1
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https://doi.org/10.1186/s12974-025-03489-1

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