IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors

IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors

Background Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted with T cells expressing chimeric antigen receptors (CARs).Meth...

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Main Authors: Jessica Wagner, Stephen Gottschalk, Giedre Krenciute, Jinghui Zhang, Shannon Lange, Jason Chiang, Liqing Tian, Deanna Langfitt, Peter Vogel, Heather Sheppard, Timothy I Shaw, Jorge Ibanez, Selene C Koo, Elizabeth Wickman, Meifen Lu, Matthew Bell, S Scott Perry, Raghuvaran Shanmugam
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009743.full
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https://jitc.bmj.com/content/12/11/e009743.full

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