Efficacy and safety of fezolinetant and its different doses in the treatment of vasomotor symptoms in menopausal women: a systematic review and meta-analysis

Abstract Introduction Fezolinetant, an oral NK3R antagonist, selectively blocks NKB signaling, improving vasomotor symptoms by reducing KNDy neuron activity. Our review assesses fezolinetant’s efficacy and safety in treating VMSs in menopausal women. Methods We conducted a systematic review and meta...

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Bibliographic Details
Main Authors: Rahma Abdelaziz Ismail, Rahma Sameh Shaheen, Eslam Afifi, Reem Sayad, Leenah N. Sherif, Mohamed Ibrahim Aranda, Rawda A. Al Gohary, Ahmed Saad Elsaeidy
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Middle East Fertility Society Journal
Online Access:https://doi.org/10.1186/s43043-025-00231-y
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