miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling

miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling

BackgroundMacrophage polarization represents a promising therapeutic target for inflammatory bowel disease (IBD). This study investigates the role of miRNA-223 (miR-223) in dextran sodium sulfate (DSS)-induced colitis and its regulation of macrophage polarization.MethodsMale C57BL/6 mice were assign...

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Bibliographic Details
Main Authors: Juanjuan Zhang, Lixin Wang, Yingye Shen, Xiaoli Qian, Zhiming Wang, Chenyang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
miR-223
DSS-induced colitis
intestinal macrophages
macrophage polarization
inflammatory bowel disease (IBD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598781/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598781/full

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