Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis

Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis

Abstract Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such changes occur in knee OA mice and their association w...

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Bibliographic Details
Main Authors: Ryo Miyake, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamada
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Brain
Subjects:
Osteoarthritis of the knee
Chronic pain
Synaptic plasticity
Anterior cingulate cortex
Exercise therapy
Voluntary running
Online Access:https://doi.org/10.1186/s13041-025-01207-9
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https://doi.org/10.1186/s13041-025-01207-9

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