The syntaxin-binding protein STXBP5 regulates progerin expression

The syntaxin-binding protein STXBP5 regulates progerin expression

Abstract Hutchinson–Gilfor progeria syndrome (HGPS) is caused by a mutation in Lamin A resulting in the production of a protein called progerin. The accumulation of progerin induces inflammation, cellular senescence and activation of the P53 pathway. In this study, through public dataset analysis, w...

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Bibliographic Details
Main Authors: Hongqian Qi, Yingying Wu, Weiyu Zhang, Ningbo Yu, Xinyi Lu, Jinchao Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Progerin
STXBP5
Lamin A
Cellular senescence
Online Access:https://doi.org/10.1038/s41598-024-74621-z
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https://doi.org/10.1038/s41598-024-74621-z

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