The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

ABSTRACT Multigene family (MGF) 360 genes, which are African swine fever virus (ASFV) virulence genes, primarily target key host immune molecules to suppress host interferon (IFN) production and interferon-stimulated gene (ISG) transcription, impairing host innate immune responses for efficient vira...

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Main Authors: Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
ASFV
MGF_360-4L
SQSTM1
MDA5
mitochondrial autophagy
Online Access:https://journals.asm.org/doi/10.1128/mbio.02677-24
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https://journals.asm.org/doi/10.1128/mbio.02677-24

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