Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer

Gastrin-releasing peptide receptor: a promising new biomarker to identify cervical precursor lesions and cancer

Abstract Objective: This study aimed to verify the relation between gastrin-releasing peptide receptor (GRPR), oncogenic Human Papillomavirus (HPV) and cervical lesions severity. Methods: GRPR mRNA levels were evaluated in cervical cancer-derived cell lines and in primary keratinocytes expressing...

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Main Authors: Martina Lichtenfels, Rafaella Almeida Lima Nunes, Rossana Veronica Mendoza López, Camila Alves da Silva, Luiz Carlos Zeferino, Vanesca de Souza Lino, Adhemar Longatto-Filho, Louise De Brot, Silvia Helena Rabelo-Santos, Daniela Baumann Cornelio, Enrique Boccardo, Caroline Brunetto de Farias, Lara Termini
Format: Article
Language:English
Published: Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 2025-03-01
Series:Revista Brasileira de Ginecologia e Obstetrícia
Subjects:
Uterine cervical neoplasms
Gastrin-releasing peptide receptor
Human papillomavirus
Papillomavirus infections
Uterine cervical dysplasia
Oncogenes
Carcinoma, squamous cell
Adenocarcinoma
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100202&tlng=en
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