Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats

Abstract Cognitive flexibility broadly describes behavioral alterations made in response to environmental changes and is fundamental for survival. While human and non-human animal assessments of cognitive flexibility are available, a systematic cross-species comparison of behavioral, neurophysiologi...

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Main Authors: Andre Der-Avakian, Samuel A. Barnes, Ty Lees, Hans S. Schroder, Brian D. Kangas, Samantha R. Linton, Stefanie Nickels, Mykel A. Robble, Micah Breiger, Ann M. Iturra-Mena, Rachel Lobien, Sarah Perlo, Emilia F. Cárdenas, Genevieve P. Nowicki, Zeyun Wu, Hongyi Pan, Daniel G. Dillon, James P. Kesby, Jack Bergman, William A. Carlezon, Victoria B. Risbrough, Eran Mukamel, Stefan Leutgeb, Diego A. Pizzagalli
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08729-x
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