Computational modeling of cancer cell metabolism along the catabolic-anabolic axes

Abstract Abnormal metabolism is a hallmark of cancer, this was initially recognized nearly a century ago through the observation of aerobic glycolysis in cancer cells. Mitochondrial respiration can also drive tumor progression and metastasis. However, it remains largely unclear the mechanisms by whi...

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Bibliographic Details
Main Authors: Javier Villela-Castrejon, Herbert Levine, Benny A. Kaipparettu, José N. Onuchic, Jason T. George, Dongya Jia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00525-x
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