The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies

Abstract HCoV-HKU1, one of seven human coronaviruses (HCoVs) that have harmful effects on human health, accounts for a substantial portion of common cold cases and can cause severe respiratory diseases in certain populations. Currently, effective antiviral treatments against this virus are limited....

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Main Authors: Zhuoqian Zhao, Qi Yang, Xiaoce Liu, Mengfei Li, Yinkai Duan, Mingjuan Du, Anqi Zhou, Huanzhen Liu, Yujia He, Wei Wang, Yuchi Lu, Xiaoyu Zhang, Haofeng Wang, Xiuna Yang, Hongkai Zhang, Xinwen Chen, Zihe Rao, Haitao Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62023-2
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https://doi.org/10.1038/s41467-025-62023-2

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