Integrated metabolomics and transcriptomics reveal the potential of hydroxy-alpha-sanshool in alleviating insulin resistance

Abstract Hydroxy-alpha-sanshool (HAS) has attracted attention because of its various biological activities, such as hypoglycemic, hypolipidemic, and antioxidant activities. In this study, we investigated the effects of HAS on insulin resistance (IR) and its mechanism. HAS reduced fasting blood gluco...

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Bibliographic Details
Main Authors: Yuping Zhu, Pan Yang, Tingyuan Ren, Zhuqi Chen, Huanhuan Tian, Mingfen Wang, Chunlin Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
Online Access:https://doi.org/10.1186/s10020-025-01129-1
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