Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway

Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway

PRKCI is abnormally expressed in various cancers, but its role in osteosarcoma is unknown. This study aimed to explore the biological function of PRKCI in osteosarcoma and its potential molecular mechanism. PRKCI expression was evaluated in osteosarcoma cell lines using Western blot analysis and rev...

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Bibliographic Details
Main Authors: Liujing Qu, Yu Xin, Jieni Feng, Xiaolei Ren, Zuming Li, Xueru Chen, Guangyan Miao, Jiankun Chen, Chengming Sun, Yue Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Oncology
Subjects:
PRKCI
osteosarcoma
proliferation
Akt/mTOR signaling pathway
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1389136/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1389136/full

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